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Before taking the oral suspensionliquidgently mix it by turning the bottle upside down 3 to 5 timesDo not shakeMeasure the liquid with a special dose-measuring spoon or cupnot a regular table spoonIf you do not have a dose-measuring deviceask your pharmacist for one.

Avoid coadministration with serotonergic psychiatric drugsegSSRIsSNRIsTCAsMAOIsunless indicated for life-threatening or urgent infectionsegvancomycin-resistant enterococcal infectionsnosocomial pneumoniacomplicated skin and skin structure infections such as methicillin-resistant S aureusdue to increased risk of serotonin syndromelinezolid may increase serotonin CNS levels by MAO-A inhibition If linezolid must be administered to a patient currently taking a serotonergic drugstop serotonergic drug immediately and monitor for CNS toxicityserotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring5 weeks if fluoxetine was takenwhichever comes firstserotonergic psychiatric medications should be stopped at least 2 weeks in advance of linezolid therapyfluoxetine should be stopped at least 5 weeks in advance due to longer half-life.

Do not use linezolid if you have taken an MAO inhibitor in the past 14 daysA dangerous drug interaction could occurMAO inhibitors include isocarboxazidmethylene blue injectionphenelzinerasagilineselegilineand tranylcypromine.

Nosocomial pneumonia caused by Staphylococcus aureusmethicillin-susceptible andresistant strainsor Streptococcus pneumoniae.

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