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Thapy with lipid-alting agnts should b only on componnt multipl isk actintvntion in individuals at signiicantly incasd isk athosclotic vascula disas du thypcholstolmia. Dug thapy is commndd as an adjunct tdit whn th spons ta dit stictd in satuatd at and cholstol and oth nonphamacologic online meds. masus alon has bn inadquat. In patints with CHD multipl isk actos CHD, atovastatin can b statd simultanously with dit.
Hmodialysis : Whil studis hav not bn conductd in patints with nd-stag nal disas, hmodialysis is not xpctd tsigniicantly nhanc claanc atovastatin sinc th dug is xtnsivly bound tplasma potins.
Slctiv Sotonin -uptak Inhibitos (SSIs) and Sotonin Nopinphin -uptak Inhibitos (SNIs): Th concomitant administation slctiv sotonin -uptak inhibitos (SSIs) and sotonin nopinphin -uptak inhibitos (SNIs) with clopidogl may act platlt activation. Hnc concomitant administation SSIs and SNIs with ATOLIP CV may incas th isk blding.
In adult patints without clinically vidnt CHD, but with multipl isk actos CHD such as ag, smoking, hyptnsion, low HDL-C, a amily histoy aly CHD, atovastatin is indicatd to.
Clinical and pathologic studis show that lvatd plasma lvls total cholstol (total-C), LDL-cholstol (LDL-C) and apolipopotin B (apB) pomot human athosclosis and a isk actos dvloping cadiovascula disas, whil incasd lvls HDL-cholstol (HDL-C) a associatd with a dcasd cadiovascula isk. Lik LDL, cholstol-nichd TG-ich lipopotins, including VLDL, IDL and mnants, can alspomot athosclosis. lvatd plasma TGs a quntly ound in a tiad with low HDL-C lvls and small LDL paticls, as wll as in association with non-lipid mtabolic isk actos coonay hat disas (CHD). As such, total plasma TG has not consistntly bn shown tb an indpndnt isk actCHD. uthmo, th indpndnt ct aising HDL lowing TG on th isk coonay and cadiovascula mobidity and motality has not bn dtmind.
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