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Synthroidlevothyroxineis a thyroid medicine that replaces a hormone normally produced by your thyroid gland to regulate the body’s energy and metabolismLevothyroxine is given when the thyroid does not produce enough of this hormone on its own.

Avoid the following food productswhich can make your body absorb less levothyroxinegrapefruit juiceinfant soy formulasoybean flourcotton seed mealwalnutsand high-fiber foods.

Rapid restoration of normal serum T 4 concentrations is essential for preventing the adverse effects of congenital hypothyroidism on intellectual development as well as on overall physical growth and maturationThereforeSYNTHROID therapy should be initiated immediately upon diagnosis and is generally continued for life.

Levothyroxine has a narrow therapeutic indexRegardless of the indication for usecareful dosage titration is necessary to avoid the consequences of overor under-treatmentThese consequences includeamong otherseffects on growth and developmentcardiovascular functionbone metabolismreproductive functioncognitive functionemotional stategastrointestinal functionand on glucose and lipid metabolismMany drugs interact with levothyroxine sodium necessitating adjustments in dosing to maintain therapeutic responsesee DRUG INTERACTIONS

The mechanisms by which thyroid hormones exert their physiologic actions are not completely understoodbut it is thought that their principal effects are exerted through control of DNA transcription and protein synthesisT 3 and T 4 diffuse into the cell nucleus and bind to thyroid receptor proteins attached to DNAThis hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins.

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