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The decision to prescribe selegiline should take into consideration that the MAO system of enzymes is complex and incompletely understood and there is only a limited amount of carefully documented clinical experience with selegilineConsequentlythe full spectrum of possible responses to selegiline may not have been observed in pre-marketing evaluation of the drugIt is advisablethereforeto observe patients closely for atypical responses.

You should not use Eldepryl if you are allergic to selegilineor if you have taken fluoxetineProzacSarafem and otherswithin the past 5 weeks.

An antidepressantcitalopramdesvenlafaxineduloxetineescitalopramfluvoxaminelevomilnacipranmilnacipranmirtazapinenefazodoneparoxetinevenlafaxinevilazodonevortioxetineand othersor.

Serious reactions with signs and symptoms that may include diaphoresisflushingataxiahyperthermiahyper/hypotensionseizurespalpitationdizziness and mental changes that include agitationconfusion and hallucinations progressing to delirium and coma have been reported in some patients receiving a combination of selegiline and fluoxetineSimilar experience has been reported in patients receiving selegiline and two other serotonin reuptake inhibitorssertraline and paroxetineThere is a potential risk of interaction with fluvoxamine and venlafaxine.

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