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Management of acute overdosage with SINEMET is the same as management of acute overdosage with levodopaPyridoxine is not effective in reversing the actions of SINEMET.

Patients should be advised that occasionallydark colorredbrownor blackmay appear in salivaurineor sweat after ingestion of SINEMETAlthough the color appears to be clinically insignificantgarments may become discolored.

If you have trouble remembering to take your tabletsask your pharmacist for some hints.

Parkinson’s disease is a progressiveneurodegenerative disorder of the extrapyramidal nervous system affecting the mobility and control of the skeletal muscular systemIts characteristic features include resting tremorrigidityand bradykinetic movementsSymptomatic treatmentssuch as levodopa therapiesmay permit the patient better mobility.

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