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There are no adequate and well-controlled studies in pregnant womenSelegiline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pharmacokinetic InformationAbsorptionDistributionMetabolism and Elimination-ADME)

Some medicines can cause unwanted or dangerous effects when used with EldeprylYour doctor may need to change your treatment plan if you use any of the following drugs:

The occurrence of stupormuscular rigiditysevere agitationand elevated temperature has been reported in some patients receiving the combination of selegiline and meperidineSymptoms usually resolve over days when the combination is discontinuedThis is typical of the interaction of meperidine and MAOIsOther serious reactionsincluding severe agitationhallucinationsand deathhave been reported in patients receiving this combinationsee CONTRAINDICATIONSSevere toxicity has also been reported in patients receiving the combination of tricyclic antidepressants and ELDEPRYL and selective serotonin re-uptake inhibitors and ELDEPRYLSee WARNINGS for detailsOne case of hypertensive crisis has been reported in a patient taking the recommended doses of selegiline and a sympathomimetic medicationephedrine

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