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Do not use diclofenac just before or after heart bypass surgery coronary artery bypass graft, or cabg .

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All eight NSAIDs are available on prescriptionwhile diclofenacnaproxen and ibuprofen are also available in lower dose over-the-counterOTCforms that can be obtained without a prescriptionPiroxicam is also available as an OTC topical medicine

You should seek advice from your doctor or pharmacist about taking this medicineThey can help you balance the risks and the benefits of this medicine during pregnancy.

The TGA reviews have found that use of OTC NSAIDs is safe when they are used according to the recommended doses for short durationsas instructed on the labelHoweverinappropriate use or overuse of these medicines can pose a significant health risk.

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furthermore, individuals with a variant of canalicular multispecific organic anion transporter 1 abcc2 c24t that leads to a decrease in the ability to export the diclofenac metabolites from the hepatocytes is also associated with increased risk 61 .

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