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Neutropenia/agranulocytosisthrombocytopenia and anaemia have been reported for patients receiving ACE inhibitorsIn patients with normal renal function and no other complicating factors neutropenia occurs rarelyNeutropenia and agranulocytosis are reversible after discontinuation of the ACE inhibitorLisinopril should be used with extreme caution in patients with collagen vascular diseaseimmunosuppressant therapytreatment with allopurinol or procainamideor a combination of these complicating factorsespecially if there is pre-existing impaired renal functionSome of these patients developed serious infectionswhich in a few instances did not respond to intensive antibiotic therapyIf lisinopril is used in such patientsperiodic monitoring of white blood cell counts is advised and patients should be instructed to report any sign of infection.

In patients undergoing major surgery or during anaesthesia with agents that produce hypotensionlisinopril may block angiotensin II formation secondary to compensatory renin releaseIf hypotension occurs and is considered to be due to this mechanismit can be corrected by volume expansion.

Postural hypotension may become aggravated by simultaneous intake of alcoholbarbiturates or anaesthetics.

This medication is used to treat high blood pressureLowering high blood pressure helps prevent strokesheart attacksand kidney problemsThis product contains two medicationslisinopril and hydrochlorothiazideLisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easilyHydrochlorothiazide is awater pilldiureticthat causes you to make more urinewhich helps your body get rid of extra salt and water.

As with other antihypertensiveslisinopril/hydrochlorothiazide combination products may have a mild to moderate influence on the ability to drive and use machinesEspecially at the start of the treatment or when the dose is modifiedand also when used in combination with alcoholbut these affects depend on the individual’s susceptibility

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