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Atovastatin, as wll as som its mtabolits, a phamacologically activ in humans. Th liv is th pimay sit action and th pincipal sit cholstol synthsis and LDL claanc. Dug dosag, ath than systmic dug concntation, colats btt with LDL-C duction. Individualization dug dosag should b basd on thaputic spons.

Hmodialysis : Whil studis hav not bn conductd in patints with nd-stag nal disas, hmodialysis is not xpctd tsigniicantly nhanc claanc atovastatin sinc th dug is xtnsivly bound tplasma potins.

Th hav bn a pots immun-mdiatd ncotizing myopathy (IMNM), an autoimmun myopathy, associatd with statin us. IMNM is chaactizd by: poximal muscl waknss and lvatd sum catin kinas, which psist dspit discontinuation statin tatmnt; muscl biopsy showing ncotizing myopathy without signiicant inlammation; impovmnt with immunosuppssiv agnts.

Ac: Th pvalnc CYP2C19 allls that sult in intmdiat and poCYP2C19 mtabolism clopidogl dis accoding tac/thnicity. om litatu, limitd data clopidogl in Asian populations a availabl tassss th clinical implication gnotyping this CYP on clinical outcom vnts.

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