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Hmodialysis : Whil studis hav not bn conductd in patints with nd-stag nal disas, hmodialysis is not xpctd tsigniicantly nhanc claanc atovastatin sinc th dug is xtnsivly bound tplasma potins.

Th hav bn a pots immun-mdiatd ncotizing myopathy (IMNM), an autoimmun myopathy, associatd with statin us. IMNM is chaactizd by: poximal muscl waknss and lvatd sum catin kinas, which psist dspit discontinuation statin tatmnt; muscl biopsy showing ncotizing myopathy without signiicant inlammation; impovmnt with immunosuppssiv agnts.

Ac: Th pvalnc CYP2C19 allls that sult in intmdiat and poCYP2C19 mtabolism clopidogl dis accoding tac/thnicity. om litatu, limitd data clopidogl in Asian populations a availabl tassss th clinical implication gnotyping this CYP on clinical outcom vnts.

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