Celebrex is approved in the us for the treatment of arthritis and pain at recommended doses of 100mg to 200mg daily for osteoarthritis and 200mg to 400mg a day for rheumatoid arthritis.
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Alternative therapies for treatment of JRA should be considered in pediatric patients identified to be CYP2C9 poor metabolizerssee Poor Metabolizers of CYP2C9 substrates
Celecoxib was not mutagenic in an Ames test and a mutation assay in Chinese hamster ovaryCHOcellsnor clastogenic in a chromosome aberration assay in CHO cells and an in vivo micronucleus test in rat bone marrow.
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