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The food and drug administration fda has asked manufacturers of prescription nsaids and the cox-2 inhibitor celecoxib celebrex to include with their products a boxed warning emphasizing the increased risk for cardiovascular events and gi bleeding in people taking these drugs.

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What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory DrugsNSAIDs

Celecoxib metabolism is primarily mediated via CYP2C9Three metabolitesa primary alcoholthe corresponding carboxylic acid and its glucuronide conjugatehave been identified in human plasmaThese metabolites are inactive as COX-1 or COX-2 inhibitors.

To minimize the potential risk for an adverse CV event in NSAID-treated patientsuse the lowest effective dose for the shortest duration possiblePhysicians and patients should remain alert for the development of such eventsthroughout the entire treatment courseeven in the absence of previous CV symptomsPatients should be informed about the symptoms of serious CV events and the steps to take if they occur.

Stop taking your NSAID and call your healthcare provider right away if you get any of the following symptoms:

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